Visual Cortex Gamma Synchronization Driver

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02:00:18

"Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)1–40 and Aβ 1–42 isoforms. Gene expression profiling revealed induction of genes associated with morphological transformation of microglia, and histological analysis confirmed increased microglia co-localization with Aβ. Subsequently, we designed a non-invasive 40 Hz light-flickering regime that reduced Aβ1–40 and Aβ1–42 levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice."
Nature 540, 230–235 (08 December 2016) doi:10.1038/nature20587
Note also the potential for trivial addition of a buzzer (or aux out for amplification and realization via low frequency capable speaker/subwoofer)
Journal of Alzheimer's Disease, vol. 52, no. 2, pp. 651-660, 2016 DOI: 10.3233/JAD-160081

published 9 years ago

eighthourlunch

9 years ago

Nice work. I made one minor, but useful modification when I built this out on a breadboard. I replaced the 3.9 K Ohm resistor with a small 5 K pot so that I could fine tune the actual result. As far as sound goes, it'd be cool to see any research on activity based on higher frequency multiples of 40 Hz that we can actually hear. Then again, if just *feeling* 40 Hz worked, that would be an interesting result as well.

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